The third generation of the Odyssey was introduced in 2005 and it used big engineering improvements in terms of materials and body engineering.
Three years later the MPV was improved.

For the 2008 model, the Odyssey received a mild update. The mid-life cycle refresh was needed since the car-market started to collapse due to the world economic crisis. To keep its customers closer, the car was better equipped than the non-facelifted version.

From the outside, there were minor changes to the headlights and the grille. In the back, a new set of taillights was introduced, to enhance both the safety and the overall image of the car. The Odyssey was offered with power sliding doors and power tailgate on the options list.

The biggest changes were inside the cabin. A new instrument cluster and a slightly different dashboard design were introduced. For all trim levels, there was a new AUX-in jack fitted as standard. While on the non-facelifted version the back-up camera was available only if the car was fitted with a navigation system, after the facelift the display for that was integrated into the rear-view mirror.

For the drivetrain, the Odyssey kept the V6 engine but enhanced. It now was available with cylinder deactivation for 2 and 3 cylinders instead of 3 as before. The transmission remained the same, with 5-speed.